Transcription profiling of mouse macrophages in response to infection with Streptococcus pyogenes

ABSTRACT: The complex response of murine macrophages to infection with Streptococcus pyogenes was investigated at the level of gene expression using a high-density oligomer microarray. More than 400 genes were identified as being differentially regulated. Many of the up-regulated genes encoded molecules were involved in immune response and inflammation, transcription, signalling, apoptosis, cell cycle, electron transport and cell adhesion. Of particular interest was the up-regulation of proinflammatory cytokines, typical of the classically activated macrophages (M1 phenotype) such as TNF-?, IL-1 and IL-6, and also the up-regulation of anti-inflammatory mediators such as IL-1ra and IL-10 associated with macrophage alternative activation (M2 phenotype). Furthermore, the gene encoding inducible nitric

ORGANISM(S): Mus musculus

SUBMITTER: Robert Geffers 

PROVIDER: E-GEOD-7769 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress