Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rakesh Verma
PROVIDER: E-GEOD-77714 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Das Rituparna R Verma Rakesh R Sznol Mario M Boddupalli Chandra Sekhar CS Gettinger Scott N SN Kluger Harriet H Callahan Margaret M Wolchok Jedd D JD Halaban Ruth R Dhodapkar Madhav V MV Dhodapkar Kavita M KM
Journal of immunology (Baltimore, Md. : 1950) 20141224 3
Combination therapy concurrently targeting PD-1 and CTLA-4 immune checkpoints leads to remarkable antitumor effects. Although both PD-1 and CTLA-4 dampen the T cell activation, the in vivo effects of these drugs in humans remain to be clearly defined. To better understand biologic effects of therapy, we analyzed blood/tumor tissue from 45 patients undergoing single or combination immune checkpoint blockade. We show that blockade of CTLA-4, PD-1, or combination of the two leads to distinct genomi ...[more]