Transcription profiling of mouse ovaries from Lhx8 Null newborns

ABSTRACT: Lhx8 is a homeobox gene expressed in oocytes and critical in oogenesis. Lhx8 deficiency leads to rapid loss of postnatal oocytes. Early oocyte differentiation is poorly understood. We hypothesized that lack of Lhx8 perturbs global expression of genes preferentially expressed in oocytes. We compared Lhx8 knockout and wild type ovaries using Affymetrix 430 2.0 microarray platform. Experiment Overall Design: Each array was hybridized with cRNA produced from pooled total RNA from at least 25 specimens. The experiment was performed with 3 replicates. The results from these three arrays was compared to arrays hybridized with cRNA produced from pooled total RNA from at least 25 wild type specimens of the same genetic background.

ORGANISM(S): Mus musculus

SUBMITTER: Aleksandar Rajkovic 

PROVIDER: E-GEOD-7774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress