The multifaceted RisA regulon of Bordetella pertussis

ABSTRACT: Bordetella pertussis, the etiological agent of whooping cough, regulates the expression of its virulence factors by the well-defined BvgA/S two-component regulatory system. Phosphorylated BvgA activates the virulence activated genes (vags) and represses via the activation of the bvgR gene the expression of the virulence repressed genes (vrgs). In the presence of MgSO4, known as modulating condition, the BvgA/S system is inactive, and the vrgs are expressed. Here, we show that, except for 6 genes of unknown function, the expression of all the vrgs depends on RisA, another transcriptional two-component regulator. In addition to the vrgs, RisA also regulates the expression of a many other genes. Whereas the expression of most vags was not affected by the deletion of risA, some vags, includin

ORGANISM(S): Bordetella pertussis

SUBMITTER: David Hot 

PROVIDER: E-GEOD-77754 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress