Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hector Georgiou
PROVIDER: E-GEOD-77830 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Georgiou E X EX Lei K K Lai P F PF Yulia A A Herbert B R BR Castellanos M M May S T ST Sooranna S R SR Johnson M R MR
Molecular human reproduction 20160526 8
<h4>Study hypothesis</h4>Myometrial explants represent a superior model compared with cell culture models for the study of human myometrial progesterone (P4) signalling in parturition.<h4>Study finding</h4>Gene expression analysis showed myometrial explants closely resemble the in vivo condition and the anti-inflammatory action of P4 is not lost with labour onset.<h4>What is known already</h4>Circulating P4 levels decline before the onset of parturition in most animals, but not in humans. This h ...[more]