HP1BP3, a chromatin retention factor for co-transcriptional microRNA processing (miRNA-Seq)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ralf Kittler
PROVIDER: E-GEOD-77855 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.
Liu Haoming H Liang Chunyang C Kollipara Rahul K RK Matsui Masayuki M Ke Xiong X Jeong Byung-Cheon BC Wang Zhiqiang Z Yoo Kyoung Shin KS Yadav Gaya P GP Kinch Lisa N LN Grishin Nicholas V NV Nam Yunsun Y Corey David R DR Kittler Ralf R Liu Qinghua Q
Molecular cell 20160714 3
Recent studies suggest that the microprocessor (Drosha-DGCR8) complex can be recruited to chromatin to catalyze co-transcriptional processing of primary microRNAs (pri-miRNAs) in mammalian cells. However, the molecular mechanism of co-transcriptional miRNA processing is poorly understood. Here we find that HP1BP3, a histone H1-like chromatin protein, specifically associates with the microprocessor and promotes global miRNA biogenesis in human cells. Chromatin immunoprecipitation (ChIP) studies r ...[more]
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