Chronic pilocarpine hydrochloride treatment induced gene expression changes in Drosophila head

ABSTRACT: Pilocarpine hydrochloride (PILO) is an epileptogenic agent. In an effort to develop a Drosophila model of kindling epileptogenesis, we have examined chronic PILO induced alterations in gene expression profile of fly heads. Expression profiling of fly heads after 7 day long PILO treatment revealed perturbations in various functional category of genes. Keywords: Drug Response D. melanogaster Oregon-R wild type flies were grown in standard fly medium consisting of agar-agar, maize powder, brown sugar, dried yeast, and nipagin. The cultures were grown at 24 +/- 1ºC, 60% RH, and 12 hrs light (9 AM to 9 PM) and 12 hours dark cycle. Three to four days old unmated adult males were grown in either normal food (NF) or food containing 1.5 mg/ml of PILO for seven days. Following this, the control an

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Abhay Sharma 

PROVIDER: E-GEOD-7787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress