Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways

ABSTRACT: Complex traits, including common disease-related traits, are affected by many different genes that function in multiple pathways and networks. The apoptosis, MAPK, Notch and Wnt signalling pathways play important roles in development and disease progression. At the moment we have a poor understanding of how allelic variation affects gene expression in these pathways at the level of translation. Here we report the effect of natural genetic variation on transcript and protein abundance involved in developmental signalling pathways in Caenorhabditis elegans. We used selected reaction monitoring to analyse proteins from the abovementioned four pathways in a set of recombinant inbred lines (RILs) generated from the wild-type strains Bristol N2 and Hawaii CB4856 to enable quantitative trait loci

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Basten Snoek 

PROVIDER: E-GEOD-77905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress