Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse kidney treated with with vancomycin to assess nephrotoxicity


ABSTRACT: The glycopeptide antibiotic vancomycin (VCM) represents one of the last lines of defense against methicillin-resistant Staphylococcus aureus infections. However, vancomycin is nephrotoxic, but the mechanism of toxicity is still unclear. The goal of this study was twofold: (1) gain insights into the molecular mechanisms of vancomycin nephrotoxicity at the genomic level and (2) evaluate potential biomarkers (gene expression profiles) of vancomycin-induced kidney injury Experiment Overall Design: Groups of 6 female BALB/c mice were treated with 7 daily iv or ip doses of vancomycin (50, 200, and 400 mg/kg) or saline, and sacrificed on Day 8

ORGANISM(S): Mus musculus

SUBMITTER: Hanna Ng 

PROVIDER: E-GEOD-7793 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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