Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

ABSTRACT: Intraindividual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in an individual, we analyzed multiple tumors from men with disseminated prostate cancer through whole-exome sequencing, array comparative genomic hybridization (CGH) and RNA transcript profiling [GSE74685], and we compared the genomic diversity within and between individuals. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 171 CRPC tumors from 63 patients. RNA was amplified prior to hybridization against a common reference pool of prostate tumor cel

ORGANISM(S): Homo sapiens

SUBMITTER: Ilsa Coleman 

PROVIDER: E-GEOD-77930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress