Regulation of gene expression by the TSPO ligand PK 11195

ABSTRACT: We hypothesized that the potential ability of the 18 kDa mitochondrial translocator protein (TSPO) to regulate gene expression may underlie its numerous reported functions, ranging from mitochondrial activity till mental disorders. Therefore, we applied microarray analysis of gene expression to U118MG glioblastoma cells. Within 1 hr the TSPO ligand PK 11195 induced changes in expression of immediate early genes and transcription factors. After 24 hrs primarily gene expression for enzymes and other proteins is changed. The associated gene products are known to affect various cellular functions: programmed cell death, cell cycle, viability, proliferation, migration, differentiation, development, tumorigenesis, and inflammatory / immune responses. Our microscopic studies showed intense TSPO

ORGANISM(S): Homo sapiens

SUBMITTER: nasra yasin 

PROVIDER: E-GEOD-77998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress