Clinical impact of a novel microRNA chemo-sensitivity predictor in gastroesophageal cancer

ABSTRACT: Background: miRNAs might be potentially useful biomarkers for prediction of response to chemotherapeutic agents, radiotherapy and survival. The aim of this retrospective study was to validate miRNA response predictors in a cohort of patients with gastroesophageal cancer in order to predict overall survival (OS) and disease-specific survival (DSS). Material and methods: The study population encompassed 53 patients treated with curative intended for loco-regional gastroesophageal cancer. miRNA expression was quantified from pre-therapeutic and diagnostic, formalin-fixed, paraffin embedded tumor specimens using Affymetrix GeneChip miRNA 1.0 Array. Based on growth inhibition of the NCI60 panel in the presence of cisplatin, epirubicine and capecitabine, a miRNA based response predictor was deve

ORGANISM(S): Homo sapiens

SUBMITTER: Mette Winther 

PROVIDER: E-GEOD-78049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress