An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response [miRNA-seq]

ABSTRACT: Estrogen receptor α (ERα) is an important biomarker of breast cancer severity and a common therapeutic target. Recent studies have demonstrated that in addition to its role in promoting proliferation, ERα also protects tumors against metastatic transformation. Current therapeutics antagonize ERα and interfere with both beneficial and detrimental signaling pathways stimulated by ERα. The goal of this study is to uncover the dynamics of coding and non-coding RNA (microRNA) expression in response to estrogen stimulation and identify potential therapeutic targets that more specifically inhibit ERα-stimulated growth and survival pathways without interfering with its protective features. To achieve this, we exposed MCF7 cells (an estrogen receptor positive model cell line for breast cancer

ORGANISM(S): Homo sapiens

SUBMITTER: Jeanette Baran-Gale 

PROVIDER: E-GEOD-78168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress