Thymic XCR1+ dendritic cells undergo a functional maturation irrespective of type I interferon and of the microflora

ABSTRACT: Dendritic cells (DC) play critical roles in central and peripheral T cell tolerance. DC found in the steady-state periphery undergo an homeostatic, tolerogenic, maturation that promotes interaction with naive T cells and induction of abortive responses. In contrast, thymic DC are thought to exist solely in an immature state. In this study, we show that XCR1+ thymic DC constitutively mature into a stage characterized by high levels of molecules involved in T cell activation. This unanticipated mature stage corresponded to a third of the XCR1+ thymic DC and fully accounted for their ability to cross-present self-antigens to developing T cells. Transcriptomic analysis of the XCR1+ DC found in thymus and steady-state periphery revealed that their maturation involves profound and convergent cha

ORGANISM(S): Mus musculus

SUBMITTER: Marc DALOD 

PROVIDER: E-GEOD-78171 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress