Gene expression linked to sleep homeostasis in murine cortex

ABSTRACT: Why we sleep is still one of the most perplexing mysteries in biology. Strong evidence, however, indicates that sleep is necessary for normal brain function and that the need to sleep is a tightly regulated process. Surprisingly molecular mechanisms that determine the need to sleep are incompletely described. Moreover, very little is known about transcriptional changes that specifically accompany the accumulation and discharge of sleep need. In this study we present an integrated 2 cross-laboratory analysis of the effects of sleep deprivation (SD) in gene expression in the mouse cortex. We also evaluate changes in gene expression genome-wide following various lengths of subsequent recovery sleep. (RS). We demonstrate that changes in gene expression specifically linked to SD or RS, and not

ORGANISM(S): Mus musculus

SUBMITTER: Lucia Peixoto 

PROVIDER: E-GEOD-78215 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress