A comparison of DNA copy number profiling platforms using a panel of melanoma cell lines

ABSTRACT: The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of the cancer genome, has facilitated the discovery of tumor suppressor genes and oncogenes. Microarray-based assays designed to detect these chromosomal copy number alterations on a genome-wide and high-resolution scale have emerged as a cornerstone technology in the genomic era. The diversity of commercially-available platforms prompted a systematic comparison of five copy number profiling assays for their ability to detect 2-fold copy number gain and loss (4n or 1n, respectively) as well as focal high-amplitude CNAs. Here, using a collection of established human melanoma cell lines, we defined the reproducibility, absolute signals, signal:noise, false-positive and false-negative rates for each

ORGANISM(S): Homo sapiens

SUBMITTER: Joel Greshock 

PROVIDER: E-GEOD-7822 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress