Quantitative Trait Locus and Brain Expression of HLA-DPA1 And Shared Immune Alterations in Psychiatric Disorders

ABSTRACT: Genome wide association studies of schizophrenia encompassing the major histocompatibility locus (MHC) were highly significant following genome wide correction. This broad region implicates many genes including the MHC complex class II. Within this interval we examined the expression of two MHC II genes (HLA-DPA1 and HLA-DRB1) in brain from individual subjects with schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and controls by differential gene expression methods. A third MHC II mRNA, CD74, was studied outside of the MHC II locus, as it interacts within the same immune complex. HLA-DPA1 and CD74 were both reduced in hippocampus, amygdala, and dorsolateral prefrontal cortex regions in SZ and BD compared to controls by specific qPCR assay. We found several novel

ORGANISM(S): Homo sapiens

SUBMITTER: Marquis Vawter 

PROVIDER: E-GEOD-78246 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress