Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

MicroRNA profiles of 84 colon adenocarcinomas and paired nontumorous

ABSTRACT: The goal of this study was to identify microRNAs that were differentially expressed in colon tumors and determine if microRNA expression profiles could predict poor cancer survival. Keywords: disease state design For these experiments, we used RNA extracted from pairs of colon adenocarcinoma tissue and adjacent nontumorous tissue. RNA from pairs of tissues were hybridized on the same day with up to 12 pairs of tissues being hybridized on a given day. To identify differentially expressed microRNAs, paired class comparison in BRB array tools was used. Samples were paired in the individual from where the tissues originated. Therefore, every tumor tissue has it's own nontumorous reference for comparison.

ORGANISM(S): Homo sapiens

SUBMITTER: Curtis Harris

PROVIDER: E-GEOD-7828 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

Schetter Aaron J AJ Leung Suet Yi SY Sohn Jane J JJ Zanetti Krista A KA Bowman Elise D ED Yanaihara Nozomu N Yuen Siu Tsan ST Chan Tsun Leung TL Kwong Dora L W DL Au Gordon K H GK Liu Chang-Gong CG Calin George A GA Croce Carlo M CM Harris Curtis C CC

JAMA 20080101 4

<h4>Context</h4>MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome.<h4>Objective</h4>To identify microRNA expression patterns associated with colon adenocarcinomas, prognosis, or therapeutic outcome.<h4>Design, setting, and patients</h4>MicroRNA microarray expression profiling of tumors and paired nontumorous tissues was performed on a US ...[more]

PMID: 18230780

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Dataset Information

MicroRNA profiles of 84 colon adenocarcinomas and paired nontumorous

Publications

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

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