Global transcriptome abnormalities of the eutopic endometrium from women with adenomyosis

ABSTRACT: Abstract: Objective: Adenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysregulation of genes and pathways in eutopic endometrium may predispose to ectopic implantation. No study, to our knowledge, has examined the global transcriptome of isolated eutopic endometrium from women with clinically significant adenomyosis. Design: Laboratory-based study with full IRB approval and consents. Material and Methods: Endometrial sampling was performed on hysterectomy specimens (proliferative phase) from symptomatic women with pathologically-confirmed diffuse adenomyosis (n=3). Controls (n=5) were normo-ovulatory subjects without adenomyosis. All subjects were free f

ORGANISM(S): Homo sapiens

SUBMITTER: Linda Giudice 

PROVIDER: E-GEOD-78851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress