Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways

ABSTRACT: Keloids are benign tumors of the dermis that form during a protracted wound healing process. Susceptibility to keloid formation occurs predominantly in people of African and Asian descent. The key alteration(s) responsible for keloid formation has not been identified and there is no satisfactory treatment for this disorder. The altered regulatory mechanism is limited to dermal wound healing, although several diseases characterized by an exaggerated response to injury are prevalent in individuals of African ancestry. We have observed a complex pattern of phenotypic differences in keloid fibroblasts grown in standard culture medium or induced by hydrocortisone. In this study Affymetrix-based microarray was performed on RNA obtained from fibroblasts cultured from normal scars and keloids

ORGANISM(S): Homo sapiens

SUBMITTER: Shirley Russell 

PROVIDER: E-GEOD-7890 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress