Microarray analysis of human monocyte-derived macrophages stimulated with dexamethasone, interferon-gamma and dexamethasone/interferon-gamma

ABSTRACT: Glucocorticoids are extensively used to treat inflammatory diseases, however their chronic intake increases the risk of mycobacterial infections. Meanwhile, the effects of glucocorticoids on innate host responses are incompletely understood. Here, we studied the direct effects of glucocorticoids on antimycobacterial host defense in primary human macrophages. We found that glucocorticoids triggered the expression of cathelicidin, an antimicrobial critical for antimycobacterial response, independent of the intracellular vitamin D metabolism. Despite upregulating cathelicidin, glucocorticoids failed to promote macrophage antimycobacterial activity. Gene expression profiles of human macrophages treated with glucocorticoids and/or IFN-gamma, which promotes induction of cathelicidin, as well as

ORGANISM(S): Homo sapiens

SUBMITTER: Mario Fabri 

PROVIDER: E-GEOD-79077 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress