Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Peripheral blood transcriptome profiles in adult male Japanese IT workers.

ABSTRACT: Analysis of transcript abundance estimates as a function generalized purpose in life and work-related dimensions of meaning. Gene expression profiling was conducted on peripheral blood samples collected from adult male employees of a Japanese technology firm. In addition to health-relevant background characteristics (age, indcome, body mass index/BMI, smoking history, heavy alcohol consumption history), participants were also assessed for hedonic and eudaimonic dimensions of generalized well-being (assesed by the Short Flourishing Scale, Keyes, C (2006). The Mental Health Continuum-Short Form (MHC-SF) for adults) and work-specific variables including job evaluation (assessed by a12-item scale tapping both perceived significance of the firmâs work, through items such as âI am proud of my companyâ and âI think my company is really good,â as well as perceived significance of oneâs own contribution to the firm's work, through items such as, âI think other employees within my company respect my workâ), and workplace interdependence and independence of the self and coworkers (using the Singelis Self-Construal Scale, Singelis, T. M. (1994). The Measurement of Independent and Interdependent Self-Construals. Personality and Social Psychology Bulletin, 20(5), 580â591). Higher values of each scale score indicate greater levels of well-being, job satisfaction, etc. Dichotomous variables were coded 0=no/absent and 1=yes/present. Valid gene expression data are available for 106 participants.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Cole

PROVIDER: E-GEOD-79092 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Work, meaning, and gene regulation: Findings from a Japanese information technology firm.

Kitayama Shinobu S Akutsu Satoshi S Uchida Yukiko Y Cole Steve W SW

Psychoneuroendocrinology 20160712

The meaning in life, typically reflected in a sense of purpose, growth, or social embeddedness (called eudaimonic well-being, EWB), has been linked to favorable health outcomes. In particular, this experience is inversely associated with the conserved transcriptional response to adversity (CTRA), which involves up-regulation of genes linked to inflammation and down-regulation of genes linked to viral resistance. So far, however, little is known about how this transcriptome profile might be situa ...[more]

PMID: 27434635

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Project description:Individual differences in basal leukocyte gene expression profiles as a function of child's and parent's perception of family stress, and as a function of parent's psychological well-being. Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 273 individuals (129 parent:child pairs + 15 parent-or-child) who were also assessed on their perceptions of family stress (both parent's and child's perception). Each dyad is labeled by a case ID, with p suffix indicating parent's gene expression profile and c suffix indicating child's gene expression profile. Variations in gene expression are analyzed as a function of both parent's perception of family stress and child's perception of family stress (using UCLA Life Stress Interview, as previously described: Hammen C (1991) Generation of stress in the course of unipolar depression. J Abnorm Psychol 100:555-561; Adrian C, Hammen C (1993) Stress Exposure and Stress Generation in Children of Depressed Mothers. Journal of Consulting and Clinical Psychology 61:354-359; Rudolph KD, Hammen C (1999) Age and gender as determinants of stress exposure, generation, and reactions in youngsters: A transactional perspective. Child Development 70:660-677). Higher values indicate greater levels of subjectively perceived family stress. Additional data are available for 107 parents who completed all 6 subscales of the Psychological Well-Being (PWB) Scale (Ryff CD (1989) Happiness is everything, or is it? Explorations on the meaning of psychological well-being. J. Pers Soc. Psychol 57: 1069-1081), resulting in scores for PWB_Total (average score across all 6 subscales) as well as scores for subscales measuring Purpose in Life (PWB_Purpose), Environmental Mastery (PWB_Environmental_Mastery), Self-Acceptance (PWB_Self_Accept), Autonomy (PWB_Autonomy), Personal Growth (PWB_Growth), Positive Relations with Others (PWB_Relationship). Higher scores indicate greater psychological well being. Also available for those individuals are measures of age (years), male gender (0/1), ethnic group (1=White, 2=Chinese, 3=Indian, 4=Other Asian, 5=Other Ethnicity), Body Mass Index (kg/m^2), heavy alcohol consumption history (0/1), smoking history (0/1), and abundance of 8 mRNA transcripts indicating the relative prevalence of major leukocyte subsets (CD3E, CD3D, CD19, CD4, CD8A, FCGR3A, NCAM1, CD14). key word: Risk prediction

Dataset Information

Peripheral blood transcriptome profiles in adult male Japanese IT workers.

Publications

Work, meaning, and gene regulation: Findings from a Japanese information technology firm.

Similar Datasets

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