Genome-wide localisation of the bromodomain protein PfBDP1 in the malaria parasite P. falciparum

ABSTRACT: During red-blood-cell-stage infection of Plasmodium falciparum, the parasite undergoes repeated rounds of replication, egress, and invasion. Erythrocyte invasion involves specific interactions between host cell receptors and parasite ligands and coordinated expression of genes specific to this step of the life cycle. We show that a parasite-specific bromodomain protein, PfBDP1, binds to chromatin at transcriptional start sites of invasion-related genes and directly controls their expression. Conditional PfBDP1 knockdown causes a dramatic defect in parasite invasion and growth and results in transcriptional downregulation of multiple invasion-related genes at a time point critical for invasion. Conversely, PfBDP1 overexpression enhances expression of these same invasion-related genes. PfBDP

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Michaela Petter 

PROVIDER: E-GEOD-79135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress