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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Hee-Woong Lim

PROVIDER: E-GEOD-79166 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.

Jager Jennifer J Wang Fenfen F Fang Bin B Lim Hee-Woong HW Peed Lindsey C LC Steger David J DJ Won Kyoung-Jae KJ Kharitonenkov Alexei A Adams Andrew C AC Lazar Mitchell A MA

The Journal of biological chemistry 20160321 20

FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erbα, a potent transcriptional repressor. Interrogation of genes induced in the absence of Rev-erbα for Rev-erbα-binding sites identified βKlotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erbα in white adipose tissue but no ...[more]

PMID: 27002153

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The Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (Microarray)

Project description:To investigate the role of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue, we performed a microarray analysis of gene expression in the epididymal white adipose tissue of wildtype and Rev-erb alpha knock-out mice. Examination of the transcriptome in epididymal white adipose tissue of Rev-erb alpha kockout mice compared to wildtype mice.

2016-07-20 | E-GEOD-79164 | biostudies-arrayexpress

The Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (ChIP-seq, eWAT)

Project description:The goal of this study is to identify the cistrome of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue. Performing Rev-erb alpha ChIP-seq on epididymal white adipose tissue from wildtype mice at 5PM when Rev-erb alpha protein level peaks in wild type (WT) mice, we were able to globally determine the genomic regions undergoing Rev-erb alpha-dependent de-repression. Examination of Rev-erb alpha binding in epididymal white adipose tissue.

2016-07-20 | E-GEOD-79165 | biostudies-arrayexpress

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

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Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo

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2013-01-01 | E-GEOD-42541 | biostudies-arrayexpress

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Project description: Not available

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Regulation of circadian behaviour and metabolism by REV-ERB-? and REV-ERB-?.

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REV-ERB? and REV-ERB? function as key factors regulating Mammalian Circadian Output.

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Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo (ChIP-Seq)

Project description:We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse livers. We also report the change of HDAC3 occupancy upon DAD mutations in NCOR and SMRT. HDAC3 enriched genomic regions in WT and NS-DADm mice livers using Illumina GAIIx.

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