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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Chronic Alcohol Consumption Alters micro-RNA Radiation Responses in the Mouse Liver

ABSTRACT: Accumulating evidence suggests that lifestyle-related factors may influence radiation responses and the resulting cancer risks through epigenetic mechanisms, such as miRNA regulations. Chronic alcohol consumption is a major risk factor for various pathologies, including alcoholic liver disease. We have recently shown that consumption of Japanese sake promotes glutathione metabolism and anti-oxidative activities in the liver of irradiated C57BL/6 mice. Here we show that chronic alcohol consumption resulted in elevated ciculating levels of the inflammatory cytokine TNF-Î± and that it triggered specific miRNA regulations (such as the upregulation of the radio-resistant miR-210) that are susceptible to influence the resulting radiation effects in the mouse liver. Japanese sake was administrated to C3H mice irradiated with 3 Gy X-rays. miRNA expression was measured in the livers of 3 mice for each experimental group.

ORGANISM(S): Mus musculus

SUBMITTER: Guillaume Vares

PROVIDER: E-GEOD-79186 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chronic Alcohol Consumption Alters micro-RNA Radiation Responses in the Mouse Liver

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Mus musculus

Project description:Chronic Alcohol Consumption Alters micro-RNA Radiation Responses in the Mouse Liver

| PRJNA315124 | ENA

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