Differential gene expression of the nosocomial pathogen Enterococcus faecalis subjected to metal stress

ABSTRACT: Emerging antibiotic resistance among clinically relevant bacteria, paired with their ability to form biofilms on medical and technical devices, represents a serious problem in terms of effective and long-term decontamination in health care environments and gives rise to an urgent need for new antimicrobial materials. Here we present the first study of the impact of AGXX®, a novel broad-spectrum antimicrobial surface coating consisting of micro galvanic elements formed by silver and ruthenium, on the transcriptome of the nosocomial pathogen Enterococcus faecalis. E. faecalis was subjected to metal stress by growing it for different periods of time in the presence of AGXX® or silver-coated steel meshes. Subsequently, total RNA was isolated and next-generation RNA sequencing was performed t

ORGANISM(S): Enterococcus faecalis

SUBMITTER: Emanuel Clauss-Lendzian 

PROVIDER: E-GEOD-79250 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress