Hypothalamic transcriptome of male mice on high fat diet, from 99 strains

ABSTRACT: Previous studies had shown that integration of genome wide expression profiles, in metabolic tissues, with genetic and phenotypic variance, provided valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice from the Hybrid Mouse Diversity Panel (HMDP), a reference resource population for cardiovascular and metabolic traits. We report numerous novel transcripts supported by proteomic analyses, as well as novel non coding RNAs. High resolution genetic mapping of transcript levels in HMDP, reveals both local and trans expression Quantitative Trait Loci (eQTLs) demonstrating 2 trans eQTL "hotspots" associated with expression of hundreds of genes. We also report thousands of alternative splicing

ORGANISM(S): Mus musculus

SUBMITTER: Yehudit Hasin-Brumshtein 

PROVIDER: E-GEOD-79551 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress