Anchoring of heterochromatin to the nuclear lamina helps stabilize dosage compensation-mediated gene repression

ABSTRACT: Higher order structure of interphase chromosomes and their spatial organization within the nucleus can have profound effects on regulation of gene expression. We show how compartmentalizing the genome by tethering heterochromatic regions to the nuclear lamina can affect gene expression during C. elegans dosage compensation. In this organism, the dosage compensation complex (DCC) binds both X chromosomes of hermaphrodites to repress gene expression two-fold, thus balancing gene expression between XX hermaphrodites and XO males. X chromosome structure is disrupted by mutations in DCC subunits. We found that X chromosome structure and subnuclear localization are also disrupted when the mechanisms that anchor heterochromatin to the nuclear lamina are defective. Strikingly, the heterochromatic

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Gyorgyi Csankovszki 

PROVIDER: E-GEOD-79597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress