Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Memory CD8+ T cells require stress-levels of acetate for optimal function


ABSTRACT: How systemic metabolic alterations during acute infections impact immune-cell function remains poorly understood. Hess and colleagues demonstrate that acetate rapidly increases during infections, which drives acetylation of GAPDH in memory CD8+ T cells and thereby catalyzes the rapid recall response. Comparison of mRNA profile of control vs. 3d acetate exposed memory OT-I T cells

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Hess 

PROVIDER: E-GEOD-79600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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