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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNAseq from disomic and trisomic fibroblasts and lymphoblastoids

ABSTRACT: RNA was sequenced from individuals Disomic and Trisomic for chromosome 21 to identify consistent changes in gene expression across individuals Cells were cultured at subconfluency and RNA harvested for sequencing

ORGANISM(S): Homo sapiens

SUBMITTER: Ahwan Pandey

PROVIDER: E-GEOD-79842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Trisomy 21 consistently activates the interferon response.

Sullivan Kelly D KD Lewis Hannah C HC Hill Amanda A AA Pandey Ahwan A Jackson Leisa P LP Cabral Joseph M JM Smith Keith P KP Liggett L Alexander LA Gomez Eliana B EB Galbraith Matthew D MD DeGregori James J Espinosa Joaquín M JM

eLife 20160729

Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells s ...[more]

PMID: 27472900

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