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RNA expression analysis of neuroblastoma cell lines treated with epigenetic drugs

ABSTRACT: The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on the neuroblastoma transcriptome was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in histone modification and DNA methylation. The neuroblastoma cell lines Be(2)-C and IMR5-75 were treated with DAC and EPZ-6438 in combination or alone. Controls were treated with solvent (DMSO). RNA was isolated and sequenced.

ORGANISM(S): Homo sapiens

SUBMITTER: Chunxuan Shao

PROVIDER: E-GEOD-79859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA methylation analysis of neuroblastoma cell lines treated with epigenetic drugs

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