Transcriptional profiling of IL-10 producing vs non producing human TFR2 cells

ABSTRACT: Background information: Antibody responses to most infectious and food protein antigens depend on help to B cells from specialised T follicular helper (Tfh) cells. A subset of Foxp3+ regulatory T cells (Tregs) has been described in mice, with a prominent role in repressing germinal center reactions that are critical for memory B cell formation and long-lived antibody responses. These specialised Tregs co-opt the Bcl-6-dependent Tfh differentiation pathway in order to access the B cell-rich follicles and have therefore been designated as T follicular regulatory (Tfr) cells. Preliminary results: We identified a unique Bcl-6-expressing follicular regulatory T cell in human secondary lymphoid tissue, designated hereafter as Tfr2 cells, that lacks Foxp3 expression and the thymic-imprinted Foxp3

ORGANISM(S): Homo sapiens

SUBMITTER: Pablo Fernandez De Canete Nieto 

PROVIDER: E-GEOD-79887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress