Activation of GCN2 by Ribosome Stalling Links Translation Elongation with Translation Initiation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jeffrey Chuang
PROVIDER: E-GEOD-79930 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.
Ishimura Ryuta R Nagy Gabor G Dotu Ivan I Chuang Jeffrey H JH Ackerman Susan L SL
eLife 20160416
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of C57BL/6J-Gtpbp2(nmf205)(-/-) mice in which neuronal elongation complexes are stalled at AGA codons due to deficiencies in a tRNA(Arg)UCU tRNA and GTPBP2, a mammalian ribosome rescue factor. Increased levels of phosphorylation of eIF2α (Ser51) were detected prior to neurodeg ...[more]
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