Transcriptional profiling of Ppr1 gain of function mutant Candida albicans strains

ABSTRACT: Metabolic pathways are largely conserved in eukaryotes, but the transcriptional regulation of these pathways can sometimes vary between species; this has been termed rewiring. Recently it has been established that in the Saccharomyces lineage starting from Saccharomyces castelli, genes involved in allantoin breakdown have been genomically relocated to form the DAL cluster. The formation of the DAL cluster occurred along with the loss of urate permease (UAP) and urate oxidase (UOX), reducing the requirement for oxygen and bypassing the candidate Ppr1 inducer, uric acid. In Saccharomyces cerevisiae this allantoin catabolism cluster is regulated by the transcription factor Dal82, which is not present in many of the pre-rearrangement fungal species. We have used ChIP-Chip analysis, transcripti

ORGANISM(S): Candida albicans

SUBMITTER: Walters Tebung 

PROVIDER: E-GEOD-79931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress