A large microRNA cluster on chromosome 19 is a transcriptional hallmark of WHO type A and AB thymomas

ABSTRACT: Thymomas are one of the most rarely diagnosed malignancies. To better understand its biology and to identify therapeutic targets, we performed next-generation RNA sequencing. The RNA was sequenced from 13 thymic malignancies and 3 normal thymus glands. Validation of microRNA expression was performed on a separate set of 35 thymic malignancies. For cell-based studies, a thymoma cell line was used. Hierarchical clustering revealed 100% concordance between gene expression clusters and WHO subtype. A substantial differentiator was a large microRNA cluster on chr19q13.42 that was significantly overexpressed in all A and AB tumors and whose expression was virtually absent in the other thymomas and normal tissues. Overexpression of this microRNA cluster activates the PI3K/AKT/mTOR pathway. Treat

ORGANISM(S): Homo sapiens

SUBMITTER: Milan Radovich 

PROVIDER: E-GEOD-79978 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress