MiRNA profiles in livers with different mass deficits after partial hepatectomy and miR-106b~25 cluster accelerating hepatocyte proliferation in rats

ABSTRACT: To query the relationship between miRNA profiles and deficits in liver mass after PH and the miRNAs linked to liver regeneration, we compared the miRNA expression profile after 2/3 PH, a standard procedure that leads to robust DNA synthesis, with that after 1/3 PH, a procedure that causes minimal replication. The patterns and dynamics of miRNA profiles after PH were featured, providing a rich resource of miRNAs underlying mechanisms of liver regeneration. We generated miRNA profiles from normal and remnant livers at 6, 12, 24, and 36 hours after 1/3 or 2/3PH using microarrays. Two or three rats were used at each time.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Zhikun Liu 

PROVIDER: E-GEOD-79983 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress