Transcription profiling of mouse heart myocardium after a single dose administration of Isoproterenol hydrochloride

ABSTRACT: Gene expression was evaluated in the myocardium of male Wistar rats after a single sc administration of 0.5 mg of isoproterenol, a β-adrenergic agonist that causes acute tachycardia with subsequent myocardial necrosis. Histology of the heart, clinical chemistry and hematology were evaluated at 9 time-points (0.5 hr to 14 d post-injection). Myocardial gene expression was evaluated at 4 time-points (1 hr to 3 d). Contraction bands and loss of cross striation were identified on phosphotungstic acid-hematoxylin-stained sections 0.5 hr post-dosing. Plasma troponin I elevation was detected at 0.5 hr, peaked at 3 hr, and returned to baseline values at 3 d post-dosing. Interleukin 6 (Il6) expression spiked at 1-3 hr and was followed by a short-lived time-dependant dysregulation of its downstream

ORGANISM(S): Rattus norvegicus

SUBMITTER: Charu Kanwal 

PROVIDER: E-GEOD-7999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress