Transcription profiling of C. elegans specific cells from the nervous system.

ABSTRACT: Background: With its fully sequenced genome and simple, well-defined nervous system, the nematode C. elegans offers a unique opportunity to correlate gene expression with neuronal differentiation. The lineal origin, cellular morphology and synaptic connectivity of each of the 302 neurons are known. In many instances, specific behaviors can be attributed to particular neurons or circuits. Here we describe microarray-based methods that monitor gene expression in C. elegans neurons and thereby link comprehensive profiles of neuronal transcription to key developmental and functional attributes of the nervous system. Results: We employed complementary microarray-based strategies to profile gene expression in the embryonic and larval nervous systems. In the MAPCeL (Micro-Array Profiling C. ele

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: David Miller 

PROVIDER: E-GEOD-8004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress