Enhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ATAC-seq]

ABSTRACT: In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates1,2. As a proto-oncogene, targeted MYCN overexpression in peripheral neural crest is sufficient to initiate disease in mouse models3. In MYCN amplified neuroblastoma, elevated expression of the factor is crucial to maintain tumor stemness4,5 and is associated with increased proliferation and aberrant cell cycle progression, as these tumors lack the ability to arrest in G1 in response to irradiation6-9. MYCN down-regulation broadly reverses these oncogenic phenotypes in a variety of neuroblastoma models10-12 and recent thereapeutic strategies to in

ORGANISM(S): Homo sapiens

SUBMITTER: James Bradner 

PROVIDER: E-GEOD-80152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress