Pathway analysis of expression QTL data in fat identifies a role for cyclin H in oxidative phosphorylation

ABSTRACT: Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across genetic mapping populations. These gene expression phenotypes have been used for genome-wide association analyses, an analysis referred to as expression QTL (eQTL) mapping. Here, eQTL analysis was performed in fat issue from 28 inbred strains of mice. We focused our analysis on “trans-eQTL bands”, defined as instances in which the expression patterns of many genes were all associated to a common genetic locus. Genes comprising trans-eQTL bands were screened for enrichments in functional gene sets representing known biological pathways, while genes located at associated

ORGANISM(S): Mus musculus

SUBMITTER: John Walker 

PROVIDER: E-GEOD-8028 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress