Transcription profiling of mouse models or Parkinsons disease reveal miRNAs and codon usage regulate striatal gene and protein expression

ABSTRACT: The molecular mechanisms underlying the changes in the nigrostriatal pathway in Parkinson’s disease (PD) are not completely understood. Here we use microarrays and mass spectrometry to study the transcriptomic and proteomic changes in the striatum of two mouse models of PD induced by distinct neurotoxins, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and methamphetamine (METH). Transcripts and proteins were found with similar abundance changes in both models which may be involved in the pathophysiology of PD. GFAP transcript and protein levels were significantly up-regulated by both neurotoxins, confirming the known astrocytic response to these drugs. Other genes and proteins were idiosyncratic in their responses to the two toxins, suggesting specific toxicological responses.

ORGANISM(S): Mus musculus

SUBMITTER: Mark Chin 

PROVIDER: E-GEOD-8030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress