ADTRP siRNA Microarray Data in HepG2 Cell Line

ABSTRACT: Coronary artery disease (CAD) and its complication myocardial infarction (MI) are the leading cause of death worldwide.Our genome-wide association studies (GWAS) in the Chinese population identified a genomic variant, rs6903956, in intron 1 of the C6orf105 gene (later named as ADTRP) as a significant risk factor for CAD and MI. Based on itscell membrane localization and its function on regulation of TFPI, we hypothesize that ADTRP acts as a cell signaling molecule that affects function and expression of many downstream genes/proteins. We performed global gene expression profiling in cells with knockdown of ADTRP expression to identify other downstream targets of ADTRP. To identify other downstream targets of ADTRP, we performed global gene expression profiling in cells with knockdown of AD

ORGANISM(S): Homo sapiens

SUBMITTER: QING WANG 

PROVIDER: E-GEOD-80469 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress