Transcriptional response to the HSP70 inhibitor MAL3-101 in parental rhabdomyosarcoma cells and isogenic acquired-resistance lines.

ABSTRACT: We demonstrate that inhibition of HSP70 with MAL3-101 induces activation of the unfolded protein response, and that cells with acquired resistance upregulate a cytosolic HSP70 at the level of mRNA. Whole transcriptome sequencing was undertaken of parental or acquired-resistance RMS13 cells treated with either DMSO or 10 micromolar MAL3-101.

ORGANISM(S): Homo sapiens

SUBMITTER: Amit Sabnis 

PROVIDER: E-GEOD-80525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress