Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Messenger RNA expression after MK2206/DMSO treatment of T47D cells

ABSTRACT: We performed RNA-seq in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that a group of transcripts is differentailly expressed after AKT inhibition. Comparison of mRNA levels using RNA-seq after AKT inhibition vs vehicle

ORGANISM(S): Homo sapiens

SUBMITTER: Koen Dreijerink 

PROVIDER: E-GEOD-80591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Post-translational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic signaling remain unclear. Here we show that H3K4me3 is increased in breast tumors driven by an activated PIK3CA allele and that inhibition of PI3K/AKT signaling reduces promoter-associated H3K4me3 in human breast cancer cells. We show that the H3K4 demethylase KDM5A is an AKT target and that phosphorylation of KDM5A regulates its nuclear loc  ...[more]

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