Gene expression of extranodal NK/T cell lymphoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Siok-Bian Ng
PROVIDER: E-GEOD-80632 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma.
Yan Junli J Li Boheng B Lin Baohong B Lee Pei Tsung PT Chung Tae-Hoon TH Tan Joy J Bi Chonglei C Lee Xue Ting XT Selvarajan Viknesvaran V Ng Siok-Bian SB Yang Henry H Yu Qiang Q Chng Wee-Joo WJ
Blood 20160613 7
The best-understood mechanism by which EZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repression, which requires its histone methyltransferase activity. However, small-molecule inhibitors of EZH2 that selectively target its enzymatic activity turn out to be potent only for lymphoma cells with EZH2-activating mutation. Intriguingly, recent discoveries, including ours, have placed EZH2 into the category of transcriptional coactivators and thus rais ...[more]
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