Candidate driver genes in SÑzary syndrome
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Venu Pullabhatla
PROVIDER: E-GEOD-80650 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome.
Woollard Wesley J WJ Pullabhatla Venu V Lorenc Anna A Patel Varsha M VM Butler Rosie M RM Bayega Anthony A Begum Nelema N Bakr Farrah F Dedhia Kiran K Fisher Joshua J Aguilar-Duran Silvia S Flanagan Charlotte C Ghasemi Aria A AA Hoffmann Ricarda M RM Castillo-Mosquera Nubia N Nuttall Elisabeth A EA Paul Arisa A Roberts Ceri A CA Solomonidis Emmanouil G EG Tarrant Rebecca R Yoxall Antoinette A Beyers Carl Z CZ Ferreira Silvia S Tosi Isabella I Simpson Michael A MA de Rinaldis Emanuele E Mitchell Tracey J TJ Whittaker Sean J SJ
Blood 20160427 26
Sézary syndrome (SS) is a leukemic variant of cutaneous T-cell lymphoma (CTCL) and represents an ideal model for study of T-cell transformation. We describe whole-exome and single-nucleotide polymorphism array-based copy number analyses of CD4(+) tumor cells from untreated patients at diagnosis and targeted resequencing of 101 SS cases. A total of 824 somatic nonsynonymous gene variants were identified including indels, stop-gain/loss, splice variants, and recurrent gene variants indicative of c ...[more]
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