Identification of TWIST1 transcriptional targets in the cranial mesoderm [ChIP-Seq]

ABSTRACT: TWIST1, a basic helix-loop-helix transcription factor is essential for the development of cranial mesoderm and cranial neural crest-derived craniofacial structures. Our previous work showed that, in the absence of TWIST1, some cells within the cranial mesoderm adopt an abnormal epithelial configuration. Here, we show by transcriptome analysis that loss of TWIST1 in the cranial mesoderm is accompanied by a reduction in the expression of genes that are associated with cell-extracellular matrix interactions and the acquisition of mesenchymal characteristics. By comparing the transcriptional profiles of cranial mesoderm-specific Twist1 loss-of-function mutant and control mouse embryos, we identified a set of genes that are both TWIST1-dependent and predominantly expressed in the mesoderm. By C

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Patrick Tam 

PROVIDER: E-GEOD-80662 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress