Meiotic behavior analysis of a balanced reciprocal translocation in the pig

ABSTRACT: Balanced constitutional reciprocal translocations are the most common structural chromosomal rearrangements identified in man and pigs. Carriers are generally phenotypically normal, but such rearrangements frequently lead to reproductive disorders. In reciprocal translocation heterozygotes, the homologous regions of the normal and derivative chromosomes involved in the rearrangement pair during the prophase of the first meiotic division, thanks to the synaptonemal complex (SC), and form a particular structure called quadrivalent. In some cases, chromosomal regions (within the quadrivalent) remain unsynapsed, especially around the breakpoints, which may trigger meiosis checkpoints leading to spermatogenesis arrest at the pachytene stage. Several hypotheses have been proposed to explain suc

ORGANISM(S): Sus scrofa

SUBMITTER: Herve Acloque 

PROVIDER: E-GEOD-80693 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress