Profiling of mouse muscle stem cells aging and activation upon skeletal muscle injury

ABSTRACT: Utilizing glycerol intramuscular injections in M. musculus provide a models of skeletal muscle damage followed by skeletal muscle regeneration. In particular, glycerol-induced muscle injury triggers accute activation of skeletal muscle stem cells, called satellite cells. However, aging dramatically impairs the regenerative capacity of satellite cells. We characterized genome-wide expression profiles of young and old satellite cells in the non-proliferative and activated state, freshly isolated to non-injured or damaged muscles, respectively. Our goal was to uncover new regulatory signaling specific to satellite cells entry into the activation and myogenic program that are affected with age. Satellite cells were isolated in either quiescent / non-proliferative or activated state from uninju

ORGANISM(S): Mus musculus

SUBMITTER: Jerome Feige 

PROVIDER: E-GEOD-81096 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress