Transcription profiling of human whole blood from pediatric septic shock patients

ABSTRACT: In an ongoing translational research program involving microarray-based expression profiles in pediatric septic shock, we have now conducted longitudinal studies focused on the temporal expression profiles of canonical signaling pathways and gene networks. Genome-level expression profiles were generated from whole blood-derived RNA samples of children with septic shock (n = 30 individual patients) corresponding to days 1 and 3 of admission to the pediatric intensive care unit. Based on sequential statistical and expression filters, day 1 and day 3 of septic shock were characterized by differential regulation of 2,142 and 2,504 gene probes, respectively, relative to normal control patients. Venn analysis demonstrated 239 unique genes in the day 1 data set, 598 unique genes in the day 3 data

ORGANISM(S): Homo sapiens

SUBMITTER: Hector Wong 

PROVIDER: E-GEOD-8121 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress